Simpson, who was acquitted of the crimes in a 1994 criminal trial, agreed to an "unrestricted" interview with book publisher Judith Regan. The two-part interview, titled "O.J. Simpson: If I Did It, Here's How It Happened," will air Nov. 27 and Nov. 29.
"O.J. Simpson, in his own words, tells for the first time how he would have committed the murders if he were the one responsible for the crimes," FOX said in a statement. "In the two-part event, Simpson describes how he would have carried out the murders he has vehemently denied committing for over a decade."
The interview will air days before Simpson's new book, "If I Did It," goes on sale Nov. 30. The book, published by Regan, "hypothetically describes how the murders would have been committed."
"It's unfortunate that 'Simpson' has decided to 'awaken a nightmare' that we have painfully endured and worked so hard to move beyond ... We hope Ms. Regan takes full accountability for promoting the wrongdoing of criminals and leveraging this forum and the actions of 'Simpson' to commercialize abuse."
She added: "We regret that Nicole's children, Sydney and Justin will be exposed to 'Simpson's' inexplicable behavior and we will provide them with our love and support during this time."
In a video clip on FOX's Web site, an off-screen interviewer says to Simpson, "You wrote 'I have never seen so much blood in my life.'"
"I don't think any two people could be murdered without everybody being covered in blood," Simpson responds.
Simpson, who now lives in Florida, was acquitted in a criminal trial of the 1994 killings of his ex-wife and Goldman, but was later found liable in 1997 in a wrongful death lawsuit filed by the Goldman family.
Messages left with Simpson and his attorney Yale Galanter were not immediately returned.
The Associated Press contributed to this report.