"I don't know if I will do that," Romano told The Associated Press. "I love standup and I haven't given it up."
Romano was among the celebrities who took part in a benefit concert for hurricane victims at the University of Mississippi on Saturday.
Romano, 47, is committed to doing a sequel to the animated film "Ice Age," where the actor voiced the wooly mammoth character Manfred.
The upcoming family film will be a family affair for Romano, whose twin sons are also doing voices for characters in "Ice Age 2: The Meltdown."
"It's great. Queen Latifah plays my mammoth girlfriend," Romano said.