Valtteri Filppula, Todd Bertuzzi and Henrik Zetterberg each had a goal and an assist, and Chris Conner, Drew Miller also scored for Detroit. Johan Franzen and Pavel Datsyuk each had two assists, and Jimmy Howard made 29 saves.
Little opened the scoring 35 seconds into the game when he beat Howard through the legs with a backhand shot off a partial breakaway. It was Little's 10th goal.
Bertuzzi tied it at at the 6:47 mark with his third goal. He put in a one-timer from Pavelec's left.
Zetterberg gave Detroit the lead with 5:04 left in the opening period. His sixth goal came on a slap shot from the top of the left circle.
The Red Wings then scored four times in the second period to break the game open. Hudler got his first goal of the game at 4:03, beating Pavelec from the left circle. Conner's first goal of the season came 40 seconds later. His shot from the right circle deflected off Winnipeg's Mark Flood and Randy Jones and into the net.
It also was the first goal as a Red Wing for Conner, who is from the Detroit suburb of Livonia. Filppula's got his 10th goal, at 9:31, and Miller's third goal capped off the scoring in the period with 7:19 left. Hudler added his second goal of the game and sixth of the season 1:12 into the third period.
NOTES: Red Wings defenseman Niklas Kronwall took a puck to the face off the stick of Andrew Ladd in the middle of the second period. Kronwall had a bloody mouth and he went to the locker room. He was back on the bench before the end of the period. ... The seven goals are a season high for Detroit, which last scored seven goals last season on Feb. 28. The Red Wings chased the opposing starting goalie for the second straight game.