Kaka and fellow Brazilian Marcelo, along with Spaniard Alvaro Arbeloa, are all sidelined with minor injuries. Kaka has a calf problem and Marcelo and Arbeloa both have thigh injuries.
Real Madrid has won its first three Champions League matches without allowing a goal, and visits Lyon on Wednesday. Real defeated Lyon, 4-0, at the Bernabeu in the clubs' first meeting in Group D.
The Spanish club will secure a berth in the knockout round with a victory.