Watch "The Big Story" weekdays at 5 p.m. ET

For the second time in a month, Republicans failed to end the debate on the president's pick for United Nations ambassador. What impact is the president's lame duck status having on his second term agenda? We'll ask Sens. Trent Lott, R-Miss., and Chris Dodd, D-Conn.

Will attacks on Hillary Clinton (search) help or hurt the Republican base? We'll get a fair and balanced debate from Dick Armey, former Texas congressman and current co-chair of Freedom Works, and Doug Hattaway, former Gore national spokesman and Democratic strategist.

Tempers flare on Capitol Hill as Rep. John Hostettler, R-Ind., accuses his Democratic colleagues of attacking Christians. The Dems want him censured for his comments — but does he have a point? We'll ask him.

Is there a connection between Al Qaeda and Iran? We'll be joined by Ken Timmerman, author of "Countdown to Crisis."

Plus, three weeks after her disappearance, Natalee Holloway's (search) family is getting some help from members of a Texas search and rescue team. We'll get an update on the search from Joe Houston of Texas EquuSearch.

Real journalism: fair and balanced. That's why we're No. 1 — FOX News Channel.

About the Show

Veteran newscaster John Gibson gets to the core of the most salient issues facing America today as host of FNC's hard-hitting primetime show "The Big Story with John Gibson."

Airing Monday through Friday at 5 p.m. ET, "The Big Story" gives you expert legal analysis from Judge Andrew Napolitano.

"The Big Story with John Gibson" is one of the reasons that FOX News Channel is the most watched news network in daytime.

Note: All guests and topics subject to change