SANTA CLARA, Calif. (AP) The 49ers will be without safety Eric Reid for the remainder of the season after having surgery to repair a biceps injury Tuesday.

''Losing him is a big loss for our defense,'' defensive coordinator Jim O'Neil said. ''(Reid's) leadership ability, his versatility, his playmaking ability will leave us with an obvious void, but it'll be a great opportunity for some other guys to step up and fill those roles.''

Reid was one of San Francisco's most talented defenders. The 2013 first-round pick lines up at inside and outside linebacker, has covered tight ends and played both safety positions. He ranks second on the team with 62 tackles behind fellow safety Antoine Bethea (66).

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