Special to Outkick The Coverage from OddsShark.com

The Indianapolis Colts are 15-0 straight up and 12-2-1 against the spread in their last 15 games against fellow AFC South teams according to the OddsShark NFL Database, but to get another divisional win tonight they will likely have to do it without their starting quarterback.

Andrew Luck (right shoulder) is expected to miss the Colts' game in Houston against the Texans. Indianapolis played without Luck last week, and had to escape with a 16-13 overtime victory at home against the Jacksonville Jaguars with veteran backup Matt Hasselbeck at the helm. Hasselbeck threw for 282 yards and one touchdown.

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The Colts had been favored by four points against the Jaguars, so the three-point overtime victory dropped them to a wallet-emptying 0-4 ATS on the season to go along with their 2-2 straight-up mark. Indianapolis also won but didn't cover against Tennessee in Week 3.

Houston is off to an even slower start than Indianapolis this season, winning (and covering the posted spread) just once in their first four games -- a 19-9 home victory over Tampa Bay as a 6-point favorite in Week 3. The Texans were thumped 48-21 by the Atlanta Falcons last weekend as 4-point road underdogs.

The Texans got star running back Arian Foster back on the field against the Falcons, but he rushed for just 10 yards on eight carries in the loss. Foster, listed as probable on the injury report for this week, is expected to have a bigger role against Indianapolis tonight.

Indianapolis enters the matchup on a five-game winning streak against Houston, going 4-0-1 ATS in those contests for their supporters. Last year the Colts beat the Texans 33-28 as a 2.5-point road favorite and 17-10 as a 7-point home favorite. Totals bettors have watched the UNDER pay out at the sportsbooks in seven of their last nine matchups.

The Thursday Night Football line opened late, but the Texans are hovering between 4.5-point and 5-point home favorites for the contest at the sportsbooks as of late Thursday afternoon.

Kickoff for the game is set for 8:25pm ET at Houston's NRG Stadium. Check out the complete Colts vs. Texans matchup report at OddsShark.com.