Johnny Manziel threw a 60-yard touchdown pass to Travis Benjamin on Cleveland's second play and connected with his wide receiver again for a clutch 50-yarder with 2:52 left, giving the Browns a 28-14 win over the Tennessee Titans on Sunday.
Benjamin also returned a punt 78 yards for a TD in the first half as the Browns (1-1) got just their third home-opening win since 1999.
Starting in place of injured Josh McCown, Manziel finished 8 of 15 for 172 yards. His last completion was vintage Johnny Football as Manziel spun to his left to avoid pressure and threw deep to Benjamin.
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Manziel won his Heisman Trophy matchup with Marcus Mariota, who threw two TD passes in the second half for the Titans (1-1), but took a pounding in his second game. The No. 2 overall pick was sacked seven times.
BUCCANEERS 29, SAINTS 19
NEW ORLEANS (AP) Jameis Winston passed for a touchdown and ran for another and Tampa Bay held on against mistake-prone New Orleans.
Winston, who was intercepted twice and sacked four times in a losing NFL debut at home a week earlier, remained largely composed in the hostile Superdome. He completed 14 of 21 passes for 207 yards and was not intercepted. He lost one fumble, but the Saints couldn't cash in.
VIKINGS 26, LIONS 16
MINNEAPOLIS (AP) - Adrian Peterson had 192 total yards and Minnesota rebounded from a rough season opener.
Peterson, playing in front of a pro-Vikings crowd for the first time in 658 days, rushed 29 times for 134 yards after receiving a pregame standing ovation out of the tunnel and a couple of ''AP! AP! AP!'' chants from the fans on a sun-soaked afternoon.
Teddy Bridgewater played a smart, sharp game for Minnesota (1-1). He threw for one touchdown and ran for another. Matthew Stafford was erratic for the Lions (0-2), who fell behind 14-0 early in the second quarter.
CARDINAL 48, BEARS 23
CHICAGO (AP) - Carson Palmer threw for four touchdowns to lead Arizona in a game that saw Chicago lose Jay Cutler to a hamstring injury.
Palmer connected with Larry Fitzgerald for three TDs, David Johnson returned the opening kickoff a club-record 108 yards and added a rushing TD. And coach Bruce Arians gained a measure of revenge after the Bears hired Marc Trestman over him in January 2013.
Arizona is 2-0; Chicago 0-2 under new coach John Fox.
STEELERS 43, 49ERS 18
PITTSBURGH (AP) - Ben Roethlisberger passed for 369 yards and three touchdowns, DeAngelo Williams tied a team record with three rushing scores for Pittsburgh.
The Steelers (1-1) converted a pair of 2-point attempts in the first half to seize momentum and had little trouble with San Francisco (1-1). Antonio Brown caught nine passes for 195 yards and two touchdowns for Pittsburgh, which rolled up 453 total yards despite having the ball for only 23 minutes.
Colin Kaepernick threw for 335 yards and two scores.
PATRIOTS 40, BILLS 32
ORCHARD PARK, N.Y. (AP) - Tom Brady threw for 466 yards - the second-most of his career - and three touchdowns in leading New England.
Julian Edelman scored two touchdowns, and the Patriots (2-0) needed to stave off a fourth-quarter rally after building a 37-13 lead through three quarters against Buffalo (1-1).
New England's Stephen Gostkowski hit a 25-yard field goal with 1:15 left. The Bills' final drive ended on the next play from scrimmage when Tyrod Taylor's pass tipped off the hands of Sammy Watkins and was intercepted by Logan Ryan.
Brady improved to 24-3 against Buffalo, and his passing yards were the most ever by a Bills opponent.
BENGALS 24, CHARGERS 19
CINCINNATI (AP) - Andy Dalton threw three touchdown passes, and Cincinnati quickly ended Philip Rivers' streak of perfect passing.
Dalton's 9-yard throw to Tyler Eifert put the Bengals (2-0) in control midway through the fourth quarter. San Diego (1-1) set up Cincinnati's first touchdown with a fumble.
Giovani Bernard took over as the running back after Jeremy Hill lost two fumbles. He finished with 123 yards.
Rivers' streak of consecutive completions ended at 22, a Chargers record. The streak was two shy of Donovan McNabb's NFL record of 24.
FALCONS, 24, GIANTS 20
EAST RUTHERFORD, N.J. (AP) - Julio Jones caught a perfect 37-yard pass from Matt Ryan, setting up Devonta Freeman's 2-yard touchdown run with 1:14 remaining, lifting Atlanta over New York.
Jones was unstoppable in the Falcons' second straight victory, tying the club record with 13 receptions, good for 135 yards. His biggest catch was down the left sideline behind Prince Amukamara in the final moments.
The Giants (0-2) blew a 20-10 fourth-quarter lead. Leonard Hankerson caught a 10-yard TD pass to bring Atlanta within three. Then Ryan guided the Falcons 70 yards to the winning score.
REDSKINS 24, RAMS 10
LANDOVER, Md. (AP) - Rookie Matt Jones ran for 123 yards and two touchdowns, an efficient Kirk Cousins avoided turnovers, and Washington held on for the win.Jones, a third-round draft pick out of Florida, scored from 39 yards in the first quarter, and from 3 with about 2 1/2 minutes left in the fourth.
The Redskins (1-1) led 17-0 at halftime, the first time they shut out an opponent in the first half since Oct. 2, 2011, also against the Rams (1-1).
PANTHERS 24, TEXANS 17
CHARLOTTE, N.C. (AP) - Cam Newton threw two touchdown passes and somersaulted into the end zone for another score for Carolina (2-0).
Newton was 18 of 37 for 195 yards and ran for 77 yards on nine carries.
The fifth-year quarterback provided the highlight of the day when he raced up the middle on a draw play and tumbled over defensive back Rahim Moore - nearly sticking the landing - for a 3-yard TD that put Carolina ahead 17-10 late in the third quarter.
Ryan Mallett started in place of Brian Hoyer and threw for 244 yards and a TD and ran for a 6-yard score for the Texans (0-2).
AP NFL website: www.pro32.ap.org and http://twitter.com/AP-NFL