No 1 Murray loses to Zverev in 4th round of Australian Open

Britain's Andy Murray changes his racket while playing Germany's Mischa Zverev during their fourth round match at the Australian Open tennis championships in Melbourne, Australia, Sunday, Jan. 22, 2017. (AP Photo/Aaron Favila) (The Associated Press)

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Germany's Mischa Zverev raises his arms while playing Britain's Andy Murray during their fourth round match at the Australian Open tennis championships in Melbourne, Australia, Sunday, Jan. 22, 2017. (AP Photo/Aaron Favila) (The Associated Press)

United States' Venus Williams makes a backhand return to Germany's Mona Barthel during their fourth round match at the Australian Open tennis championships in Melbourne, Australia, Sunday, Jan. 22, 2017. (AP Photo/Aaron Favila) (The Associated Press)

MELBOURNE, Australia – Top-seeded Andy Murray is out of the Australian Open, the five-time finalist losing in four sets in a Sunday afternoon upset to Mischa Zverev.

The No. 50-ranked Zverev attacked Murray and unsettled the five-time finalist. The lefthander won 65 of 118 points at the net in a 7-5, 5-7, 6-2, 6-4 upset on Rod Laver Arena.

Murray joins six-time defending champion Novak Djokovic, beaten in the second round by wild-card entry Denis Istomin, on the sidelines for the second week at Melbourne Park.

It's the first time since 2002 that neither the No. 1 nor the No. 2 seed has reached the Australian Open quarterfinals.

Murray had not lost to a player ranked as low at a major in a decade since his loss to No. 51 Juan Ignacio Chela at Melbourne Park in 2006. It was also the earliest exit by a top-seeded player at the Australian Open since Lleyton Hewitt's third-round departure in 2003.

And this not even the Zverev brother tipped to go this far at the Australian Open. The 19-year-old Alexander Zverev, widely touted as a potential major winner, led by two sets to one before losing to 14-time Grand Slam champion Rafael Nadal in the third round on Saturday.