Private investigators are looking into 30 new reported sightings of Madeleine McCann, Sky News reported.
The calls came after her parents appeared on Oprah Winfrey's talk show to mark the two year anniversary of her disappearance.
There have also been thousands of new hits on the Find Madeleine Web site.
"All of the calls are being checked out and where there is a shred of hope they are being investigated," said McCann spokesman, Clarence Mitchell.
Two former British detectives are now working for the campaign and will be handling the new information.
It's thought the potential sightings were made in North and South America as well as a handful in Europe.
Kate and Gerry McCann flew to the U.S. to publicise the second anniversary of Madeleine's disappearance.
They also visited The National Centre for Missing and Exploited Children in Washington, where experts created a new image of Madeleine at age 6.
Get all the stories you need-to-know from the most powerful name in news delivered first thing every morning to your inbox