A single-engine plane crashed Tuesday afternoon just after taking off from a suburban Cleveland airport, killing two, the Federal Aviation Administration said.

The Buffalo, N.Y.-bound plane went down just after 4 p.m. in Mayfield Village, about three miles east of Cuyahoga County Airport, FAA spokeswoman Elizabeth Isham Cory said.

There was no word on how many people were on board. Police and firefighters at the scene were not immediately available for comment.

Village resident Larry Puskas, 48, said he was pulling out of his driveway when he heard strange rumbling sound and then saw a plume of smoke. He ran to the crash scene and saw some wreckage and a fire.

"You couldn't even tell it was a plane," Puskas said. "I couldn't discern anything, and I didn't see any person or body."

The plane crashed a few hundred yards away from the nearest residence, Puskas said.

Carmen Miozzi, 42, a general contractor who lives about a block from the scene, heard the crash while making dinner about 4:15 p.m.

"We heard the motor rev really high and then the next thing we heard was a 'boom' and I said to my wife, 'That had to be a plane crash.' We walked out on our deck and just saw a big cloud of smoke to the north of us," he said.

He said he went to the crash site and saw the wreckage, but saw no survivors or bodies.

"There's nothing left that looks like a plane," he said. "It was burning pretty good when I got there."