The 38-year-old actor-comedian was practicing Monday for a charity race to promote his upcoming film, "Redline," when he drove too fast around a curve at the Irwindale Speedway. Video footage shows the red sports car screeching before it ricocheted off the barrier with heavy damage to its front.
"Undercover Brother's good at karate and all the rest of that, but the Brother can't drive," said Griffin, referring to his 2002 movie, after the accident.
The film's publicist, Wendy Zocks, said Griffin was "doing OK."
"He walked away completely unscratched, but probably a little shaken," Zocks said.
The Enzo is owned by "Redline" executive producer Daniel Sadek, whose exotic car collection is featured in the movie.
Sadek said the Enzo was damaged beyond repair.
"I'm glad Eddie came out of the crash OK, but my dream car got destroyed," Sadek said. "I went to my trailer for about 15 minutes and I thought,`There's people dying every day. A lot of worse things are happening in the world."'
Only 400 Ferrari Enzos were produced, all between 2002 and 2004.
Griffin's film credits also include "Norbit," "Undercover Brother," "Deuce Bigalow: Male Gigolo" and its sequel, and "Date Movie."