"I look at having a line of cards as another extension of being a host; helping you wish your loved ones well, piggybacking on your birthday greetings," DeGeneres, 49, said in a statement Tuesday. "I like to be up in the middle of everything and doing it this way is much easier than crashing parties."
The cards are expected to be available in stores this summer.
DeGeneres has a syndicated talk show, "The Ellen DeGeneres Show," and she was the host of this year's Oscars.
American Greetings has a new focus on humor cards, said spokesman Megan Ferington. It had a previous licensing deal with comedian Jeff Foxworthy.