Frantic family members are pleading for help in the search for a South Carolina husband and wife who seem to have vanished on their way to New York City last week.

Wayne and Dianne Guay, of Myrtle Beach, S.C., were expected in the Ridgewood section of Queens on Thursday night for an early holiday visit, said Daniel Rodriguez, their son-in-law. They were expected to make a 4 a.m. start that morning and drive straight north to their former neighborhood.

The family rented a helicopter to do its own 50-mile sweep around Myrtle Beach, said Rodriguez, called 100 area hospitals and scores of police departments up and down Interstate 95, according to The New York Post.

Family members had spoken to the couple, Wayne a former employee of New York's Department of Sanitation and Dianne a former city school employee, on Wednesday night, Rodriguez said.

On Thursday, midday calls to their cell phone went straight to voice mail, and when they hadn't shown up by evening, "we started getting nervous," Rodriguez said.

"When it started hitting 8 or 9 o'clock with no phone call we knew something was wrong," he said.

Family members called state troopers along Interstate 95, the route the couple was expected to take, but there was no word of any accidents.

Rodriguez said the couple's son had gone to their house in South Carolina, but hadn't found anything out of the ordinary. The couple was traveling with luggage as well as holiday gifts.

The couple's daughter, Megan Guay, said she last spoke to her parents the night before they planned their trip, an annual 12-hour drive they make to celebrate Christmas and Megan's birthday early.

"This is unlikely of them," Megan told The New York Post. "They always call when they're on the road. Even when there's no traffic, even when they're making good time."

Megan, who flew down to Myrtle Beach with her husband on Friday, told FOX News on Monday that she has not yet been contacted by authorities about her parents' disappearance.

"They're not following through — they're dragging their feet because they don't have what it takes to find them and we need all law enforcement involved," Megan said.

Megan told the Post that the family filed a missing-persons report with the Horry County, S.C., police, but no search-and-rescue teams have been activated.

The NYPD confirmed to the Post that it was assisting South Carolina authorities.

The Guays' car is described as a four-door white 2003 Mazda 3 with South Carolina license plates 732 RSS.

The car, the Guays' luggage and the valuable coin collection Wayne Guay owned were all gone from the house, according to Megan Guay.

The Associated Press contributed to this report.