"One of the best things for a woman to hear is that she is sexy," the 21-year-old actress, star of "Match Point" and "Lost in Translation," said in a statement. "I'd like to thank FHM's readers for the huge compliment."
Angelina Jolie is No. 2 on the list, followed by Jessica Alba, Jessica Simpson, Keira Knightley, Halle Berry, Jenny McCarthy, Maria Sharapova, Carmen Electra and Teri Hatcher.
Johansson ranked ninth on last year's list. Jolie was No. 1.
"It's remarkable how Scarlett Johansson has caught the attention of our readers," said Scott Gramling, the magazine's U.S. editor in chief, in a statement. "Her sultry voice and striking beauty certainly have a lot to do with that, but so does the confidence she exudes."
"She seems to be one of those women who would be equally at ease on the red carpet as she would just hanging out with the guys."
The magazine's May issue goes on sale April 4.