Guests and Topics: Oct. 21

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October 21:

Bracing for the storm! As Wilma's (search) eyewall pummels Mexico, residents of Florida are packing up and heading out in hopes of evading the catastrophic 'cane. We'll check in with Florida Rep. Katherine Harris for an update. And we'll track Wilma's path of destruction to tell you where she's headed next.

Then, money laundering? Conspiracy charges? What lies ahead for former House Majority leader Tom DeLay (search) as he faces the fight of his political life? We're all over the story, tonight!

Also, is Harriet Miers' (search) nomination falling through? “The Case for Hillary Clinton” author Susan Estrich debates politics on tonight’s show with former Reagan campaign manager Ed Rollins.

And, we’ll have new details in the shocking murder mystery behind the brutal slaying of Pamela Vitale (search). What led the boy described by classmates as a “Gothic” loner to unleash such a horrific act of rage? Why would he beat her to death with a strip of crown molding and then carve a Goth symbol on her back? Can he be tried as an adult for the gruesome homicide? Family friend and defense attorney Debra Opri weighs in. Then, we’ll go inside the crime scene with forensic pathologist Dr. Michael Baden.

Plus, the U.S. Coast Guard (search) seized 150 tons of cocaine being smuggled into the country last year and we have exclusive video of the raids at sea. Don’t miss it!

These stories and much more ... don't miss "Hannity & Colmes" tonight at 9 p.m. ET!

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About the Show

Fast-paced and hard-hitting, "Hannity & Colmes" brings viewers a heated discussion in a nightly face-off. Relishing in controversial topics, personalities and social issues, conservative radio commentator Sean Hannity and liberal radio personality Alan Colmes offer their points-of-view in an often animated, always compelling debate.

But, unlike similar debate shows — which often appear scripted — "Hannity & Colmes" conducts a live, spur of the moment deliberation on politics and social topics. Also, differentiating the show is its dedication to "move away from the Beltway," bringing audiences an alternative discussion program without the "in" comments.

Adding fuel to the fire, several high-profile guests have joined the program on a wide-range of topics.

"With guests who are 'in the middle of the fight,' we're able to hear their point-of-view on the topics, as well as advance our own feelings," said Hannity.

"Believe it or not, I agree with that statement," quipped Colmes.