Watch "The Big Story Weekend" Saturday and Sunday at 9 p.m ET

Saturday, September 17

New Orleans Mayor Ray Nagin (search) announces that the Crescent City will begin to reopen to businesses this weekend and the first group of residents will be allowed to return to their homes on Monday. But is it too soon to return to the once-toxic city? We'll ask Dr. Brobson Lutz, former director of health of New Orleans.

Then, not only did court documents wash away in Hurricane Katrina (search), some prisoners escaped during the chaotic evacuations. How are officials dealing with this dangerous disaster? We'll ask former FBI agent Bill Daly.

And, we'll get reaction from Michael Hatton whose mother's killer escaped during Katrina.

Plus, Beth Holloway Twitty is still in Aruba fighting for answers in daughter Natalee's disappearance. We'll get an update from Natalee's stepmother, Robin Holloway.

Sunday, September 18

We'll be joined by:

Janet Pelasara, mother of missing student Taylor Behl
Dr. Michael Baden, forensic pathologist
Pat Brosnan, former NYPD homicide detective
Beth Holloway Twitty, Natalee Holloway's mother

Real journalism: fair and balanced. That's why we're No. 1 — FOX News Channel.