Watch "Hannity & Colmes" weeknights at 9 p.m. ET!

Here's just some of what we've got planned for you this evening!

As the September Senate showdown draws near, People for the American Way (search) releases a blistering report opposing the confirmation of Judge John Roberts (search) to the Supreme Court. Is this what we can expect over the next two weeks? We’ll debate it with radio talk show host Michael Reagan and democratic strategist Michael Brown.

Then, don’t say we didn’t tell you so! Acknowledging public frustration over illegal immigrants and citing that the American public is “rightly distressed” about the lack of border control, the nation's top immigration official announces new initiatives to strengthen the country’s borders. Will Secretary of Homeland Security Michael Chertoff's (search) efforts solve the problem once and for all? We'll ask Texas Senator Kay Bailey Hutchison. And, is it possible to build a giant fence along the entire border? Congressman Steve King thinks so and he's here tonight to explain how. Plus, check out our exclusive new video taken along the El Paso border and see for yourself just how easy it is for illegals to enter the country.

Also, where are cops focusing their attention in the Natalee Holloway (search) mystery? Natalee's aunt, Linda Allison, will be here with an update on the investigation.

Then, new clues surface in the case of missing Connecticut groom George Smith (search) and police are putting the heat on this cold case! Smith, who was honeymooning onboard the "Brilliance of the Seas" (search) cruiseship with his new bride, Jennifer Hagel (search), was reported missing July 5 after blood was found on the side of the ship. Did Turkish authorities botch the investigation? Was a crewmember involved? Maritime attorney Jack Hickey has the latest.

These stories and much more... Don't miss YOUR chance to join the debate tonight!

Real journalism: fair and balanced. That's why we're No. 1 — FOX News Channel.

About the Show

Fast-paced and hard-hitting, "Hannity & Colmes" brings viewers a heated discussion in a nightly face-off. Relishing in controversial topics, personalities and social issues, conservative radio commentator Sean Hannity and liberal radio personality Alan Colmes offer their points-of-view in an often animated, always compelling debate.

But, unlike similar debate shows — which often appear scripted — "Hannity & Colmes" conducts a live, spur of the moment deliberation on politics and social topics. Also, differentiating the show is its dedication to "move away from the Beltway," bringing audiences an alternative discussion program without the "in" comments.

Adding fuel to the fire, several high-profile guests have joined the program on a wide-range of topics.

"With guests who are 'in the middle of the fight,' we're able to hear their point-of-view on the topics, as well as advance our own feelings," said Hannity.

"Believe it or not, I agree with that statement," quipped Colmes.