Watch "Hannity & Colmes" weeknights at 9 p.m. ET!

Here's just some of what we've got planned for you:

A new suspect shakes up the Natalee Holloway (search) investigation. Are the missing Alabama teen's parents beginning to lose patience with the police? Alan’s LIVE from Aruba with the latest on the search for Natalee.

Plus, bestselling author Ed Klein previews his controversial new book "The Truth About Hillary Clinton: What She Knew, When She Knew It, and How Far She'll Go to Become President."

These stories and much more ... Don't miss your opportunity to join the debate tonight at 9 p.m. ET!

Real journalism: fair and balanced. That's why we're No. 1 — FOX News Channel.

About the Show

Fast-paced and hard-hitting, "Hannity & Colmes" brings viewers a heated discussion in a nightly face-off. Relishing in controversial topics, personalities and social issues, conservative radio commentator Sean Hannity and liberal radio personality Alan Colmes offer their points-of-view in an often animated, always compelling debate.

But, unlike similar debate shows — which often appear scripted — "Hannity & Colmes" conducts a live, spur of the moment deliberation on politics and social topics. Also, differentiating the show is its dedication to "move away from the Beltway," bringing audiences an alternative discussion program without the "in" comments.

Adding fuel to the fire, several high-profile guests have joined the program on a wide-range of topics.

"With guests who are 'in the middle of the fight,' we're able to hear their point-of-view on the topics, as well as advance our own feelings," said Hannity.

"Believe it or not, I agree with that statement," quipped Colmes.