Louis-Dreyfus will play a divorced mother and owner of a women's 30-minute-workout gym who must contend with her ex-husband's new young girlfriend, also named Christine, CBS (search) said Friday.
No other cast members were announced.
Louis-Dreyfus, 44, won an Emmy for her role as Elaine Benes on NBC's "Seinfeld," which ran from 1990-1998.
She had a short-lived sitcom, "Watching Ellie," (search) in 2002.
Former "Seinfeld" (search) stars Michael Richards and Jason Alexander also have had shows that flopped. Alexander's most recent comedy, "Listen Up," lasted one year.
Earlier this year, Louis-Dreyfus reprised her guest role as Maggie Lizer on Fox's "Arrested Development."