Tonight on Special Report with Brit Hume:

A homicide bomber blows herself up at the entrance to a shopping center in the northern Israeli town of Afula (search), killling four people and wounding as many as 15 others.

Now, the progress of a U.S.-backed Mideast peace initiative appears to be in jeopardy. The spate of bombings underscores how difficult it will be to carry out the U.S.-backed "road map" plan (search), a three-stage prescription for ending violence immediately and setting up a Palestinian state by 2005.

Plus:

• Ari Fleischer (search) is resigning as White House press secretary. The public face of the Bush administration through two wars and a terrorist attack, Fleischer said he plans to enter the private sector. His replacement will likely be deputy press secretary Scott McClellan.

• President Bush welcomes Philippine President Gloria Macapagal Arroyo to the White House, saying both nations are threatened by terrorism and "determined to fight that threat until it is defeated."

• Coalition forces in Iraq say they captured the brother-in-law of toppled President Saddam Hussein. Luay Khayrallaha, No. 152 on the coalition's most-wanted list, was taken into custody.

Details on these stories and more on Special Report with Brit Hume.
— Guests and topics are subject to change