The Columbia astronauts' remains, however fragmentary, will be analyzed at the same center that identified the remains of the Challenger astronauts and the Pentagon victims of the Sept. 11 terrorist attack.
And while experts say they do not expect problems identifying the astronauts, details about exactly how the seven crew members died and how quickly could be elusive.
The few remains that have been found in rural east Texas will be analyzed at the Charles C. Carson Center for Mortuary Affairs at Dover Air Force Base in Delaware, which has identified bodies in other disasters.
Forensics experts said they are confident that Columbia crew members can be genetically identified even though the space shuttle disintegrated 39 miles overhead.
Among the remains recovered are a charred torso, thigh bone and skull with front teeth, and a charred leg. An empty astronaut's helmet also could contain some genetic traces.
"DNA analysis certainly can do it if there are any cells left," said Carrie Whitcomb, director of the National Center for Forensic Science in Orlando, Fla. "If there is enough tissue to pick up, then there are lots of cells."
Nor does the DNA have to come from soft tissue.
"Identification can be made with hair and bone, too," said University of Texas physicist Manfred Fink. "Unless the body was very badly burned, there is no reason why there shouldn't be remains and it should not hinder the work."
DNA isn't the only tool available. Despite the extreme nature of the accident, simpler identification methods, such as fingerprints, can be used if the corresponding body parts survived re-entry through the atmosphere.
Dental records and X-rays from astronauts' medical files can provide matching information, making the discovery of the skull and the leg particularly valuable, they said.
But forensic experts were less certain whether laboratory methods could compensate for remains that were contaminated by the toxic fuel and chemicals used throughout the space shuttle.
"Those would be new contaminants that we haven't dealt with before," Whitcomb said.
Despite the hundreds and hundreds of debris sightings swamping law enforcement officials in Texas, recognizable portions of the crew's capsule had not yet been found.
"If the bodies had been removed from the safeguard of the cabin, they would have totally burned up and very little could be recovered," Fink said. If the bodies were shielded by portions of the cabin until impact with the ground, he said, identification would be easier.
Disasters such as the World Trade Center attack pushed the science of identification technologies to use new methods, chemicals and analytical software to identify remains that had been burned or pulverized. Researchers said they can work not only with much smaller biological samples, but smaller fragments of the genetic code itself that every human cell contains.
In the 1986 Challenger explosion, an external fuel tank explosion ripped apart the spacecraft 73 seconds after liftoff from the Florida coast. Questions about the demise of the Challenger crew persisted during the investigation that followed.
Challenger's nose section, with the crew cabin inside, was blown free from the explosion and plummeted 8.7 miles from the sky. NASA learned from on-board voice recorders that the astronauts lived through much of the capsule's death plunge. The capsule shattered after hitting the ocean at 140 to 180 mph.
Two years after the disaster, NASA officials said forensic analysis did not specifically reveal conclusive evidence about either the cause or time of the astronauts' death.
On Saturday, Columbia's crew had no chance of surviving after the shuttle broke up at 207,135 feet above Earth. The spacecraft was exposed to re-entry temperatures of 3,000 degrees while traveling at 12,500 mph, or 18 times the speed of sound.
After the 1996 crash of TWA flight 800 off Long Island, scientists were able to identify all 230 victims from tissue fragments collected from the ocean. An identification rate of 100 percent was almost unheard of at the time.