Tonight on Special Report with Brit Hume:

After months of speculation over whether he indeed would step down, U.S. Treasury Secretary Paul O'Neill abruptly annonces his resignation, becoming the first member of President Bush's Cabinet to leave.

Plus:

• Customs agents raid a Boston-area software company as part of an investigation into the firm's possible ties to terrorists.

• A mass of paper will be airlifted from Baghdad to New York this weekend, a document of thousands of pages whose dull recitation of chemical processes and medical research may help set the course of war and peace in this part of the world.

• Israeli troops backed by tanks and helicopter gunships hunt a fugitive militant in a crowded refugee camp in the Gaza Strip, setting off chaotic gunbattles that killed 10 Palestinians, including two U.N. workers.

• Venezuela's oil exports ground to a halt, negotiations stall and protesters face off on the streets as prospects dim for a peaceful resolution to a strike designed to unseat President Hugo Chavez.

Details on these stories and more on Special Report with Brit Hume.
— Guests and topics are subject to change