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Serena Williams, Andy Murray headline Day 2 at Wimbledon

  • Serena Williams of the U.S practices during a preview day at the The All England Lawn Tennis and Croquet Club, London, Saturday, June 25, 2016. The Wimbledon tennis tournament begins on Monday, June 27. (Adam Davy/PA via AP)     UNITED KINGDOM OUT        -     NO SALES        -     NO ARCHIVES

    Serena Williams of the U.S practices during a preview day at the The All England Lawn Tennis and Croquet Club, London, Saturday, June 25, 2016. The Wimbledon tennis tournament begins on Monday, June 27. (Adam Davy/PA via AP) UNITED KINGDOM OUT - NO SALES - NO ARCHIVES  (The Associated Press)

  • Serena Williams of the U.S gives her pre-Championships press conference at The All England Lawn Tennis Club, ahead of the Wimbledon Tennis Championships in London, Sunday, June 26, 2016. (Florian Eisele/Pool Photo via AP)

    Serena Williams of the U.S gives her pre-Championships press conference at The All England Lawn Tennis Club, ahead of the Wimbledon Tennis Championships in London, Sunday, June 26, 2016. (Florian Eisele/Pool Photo via AP)  (The Associated Press)

  • Andy Murray of Britain plays a shot ahead of the Wimbledon Tennis Championships in London,  Sunday, June 26, 2016. (AP Photo/Ben Curtis)

    Andy Murray of Britain plays a shot ahead of the Wimbledon Tennis Championships in London, Sunday, June 26, 2016. (AP Photo/Ben Curtis)  (The Associated Press)

Serena Williams and Andy Murray both face potentially easy opening matches against lowly ranked opponents on Day 2 at Wimbledon.

Defending women's champion and six-time winner Williams opens play on Centre Court against 148th-ranked Swiss qualifier Amra Sadikovic, making her first appearance in the main draw of a Grand Slam tournament.

Since winning last year's title, Williams has come up short in the majors, losing in the semifinals at the U.S. Open and finals of the Australian and French Opens. She needs one more Grand Slam championship to equal Steffi Graf's Open-era record of 22 titles.

Murray, the 2013 Wimbledon champion, will be up second on Centre Court on Tuesday against Liam Broady, a British wild-card entry ranked No. 235. It's the first all-British men's meeting at Wimbledon since 2001 and first at a Grand Slam since 2006.