Holger Badstuber's injury woes returned on Saturday when the Bayern Munich defender broke his ankle in training ahead of Sunday's Bundesliga trip to Augsburg.
The club announced the 26-year-old was taken to hospital for surgery and will be out for three months.
It is the latest in a catalogue of injuries which have plagued the Germany international's career over recent years.
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A cruciate ligament tear in December 2012 forced him to spend the best part of two years on the sidelines and a tendon tear four months after his comeback ruled him out for another four months before he returned in January 2015.
Last April, a thigh muscle tear kept him out for a further six months and he only returned in November.
He had made just seven appearances in his latest comeback.
Badstuber's injury is a further blow for Bayern coach Pep Guardiola, who is already without Jerome Boateng and Javi Martinez.