SAN DIEGO (AP) -- Tyson Ross lost his final start of the season after allowing Jean Segura's two-run homer, and Matt Kemp left the game with a sore hand after getting his 100th RBI.
The 4-3 loss to the Milwaukee Brewers on Tuesday night sort of summed up the Padres' season -- a few good things, but not enough.
Ross "gave us a chance to win every night he pitched," interim manager Pat Murphy said. "It pains me when Tyson pitches well and doesn't get the win."
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Segura hit a go-ahead, two-run homer in the sixth inning to help Jorge Lopez win his major league debut.
Lopez (1-0) allowed three runs and eight hits in five innings, struck out seven and walked two. The 22-year-old's contract was selected a week earlier from Double-A Biloxi, where he went 12-5 with a 2.26 ERA in 24 starts. He was named the Southern League Pitcher of the Year and the Brewers' Minor League Pitcher of the Year.
The Brewers trailed 3-2 going into the sixth. Khris Davis singled to left and Segura hit a one-out homer off Ross (10-12) into the balcony on the third level of the Western Metal Supply Co. Building in the left-field corner. It was the sixth homer for Segura, who also hit an RBI double in the first.
Francisco Rodriguez pitched the ninth for his 38th save in 40 chances.
Kemp, the centerpiece of an offseason roster redo that failed to produce a winning team, reached 100 RBIs for the first time in five seasons.
Kemp singled in Yangervis Solarte in third inning, giving him 100 RBIs. Acquired from the NL West rival Los Angeles Dodgers in December, Kemp hadn't driven in that many runs since 2011, when he had a career-high 126.
Kemp later left the game with a sore right hand.
"The other day when I was swinging it started irritating me," Kemp said. "Every time I swing I feel a little pain. I wanted to go on. I'd rather have 80 RBIs and go to the playoffs."
The Padres opened their final home series. They failed to meet preseason expectations after a big roster overhaul and will finish with their fifth straight losing season.
The Brewers jumped on Ross for a 2-0 lead in the first, on an RBI single by Adam Lind and Segura's run-scoring double.
Kemp drove in San Diego's first run in the third, and the Padres went ahead in the fourth on RBI singles by Ross and Wil Myers in the fourth.
Ross, making his final start of the season, allowed four runs and six hits in six innings, struck out seven and walked three.
"I didn't have a good rhythm early," Ross said. "It's hard to find your tempo with runners on base."
Ross said he learned a lot this year.
"I had a better second half than the first. This year has definitely been a confidence builder. I backed up what I did last year."
Brewers: RHP Zach Davies (2-2, 4.67 ERA) is scheduled to start the middle game of the series.
Padres: RHP Andrew Cashner (6-15, 4.21 ERA) is scheduled to make his final start of the season.