(SportsNetwork.com) - Jon Lester tries to get himself and the Chicago Cubs back into the win column when he takes the mound Wednesday against the Miami Marlins in the rubber match of a three-game series.

The Cubs have lost each of Lester's last two starts after winning the previous five and the left-hander dropped a 3-0 decision versus the Washington Nationals last Wednesday, charged with only two runs (1 earned) in seven innings. Lester struck out 10 and walked two.

Lester was 4-0 in six appearances and has a 4-3 record with a 3.30 earned run average over 10 starts with his new team. He has faced the Marlins twice in his career and is 0-1 with a 3.60 ERA.

Chicago had a two-game winning streak stopped with Tuesday's 5-2 loss, as Kyle Hendricks was saddled with the loss for allowing four runs and seven hits in six innings. He struck out seven and walked a pair of batters.

Junior Lake went 2-for-4 with two doubles and an RBI, while Dexter Fowler recorded two hits and scored a run for the Cubs, who will also visit Washington and Detroit on this nine-game trek.

The Marlins ended a two-game slide and won for the third time in the last five tries with Tuesday's win. Brad Hand was solid through six innings on the hill and gave up two runs and six hits.

"You gotta look at Brad Hand, setting the tone the way he did," Marlins manager Dan Jennings said. "He set the tone right away."

Giancarlo Stanton hit his 16th home run and Marcell Ozuna finished with two hits and three RBI.

After hosting the Cubs, the Marlins will visit Colorado and Toronto.

Dan Haren will toe the rubber for Miami Wednesday and is 5-2 with a 3.03 earned run average in 10 starts. Haren prevailed his last time out in a 4-3 win at the New York Mets and hurled seven innings of two-run ball.

Haren, a right-hander, is 4-1 in his last five decisions and will make his eighth career start against the Cubs. He is 2-3 with a 5.71 ERA in the first seven starts in this series.

The Cubs went 4-2 against Miami in 2014 and have won five of the last eight matchups in this series. The Marlins will visit Wrigley Field for three games in early July.