Tom Brady threw four touchdown passes and posted his 60th career 300-yard game to lead the New England Patriots to a 37-22 win over the Buffalo Bills on Sunday.

Brandon LaFell had two touchdown catches, including a 56-yarder, and the Patriots' defense forced three turnovers that resulted in 13 points in the second quarter. Brady finished 26 of 36 for 352 yards to spoil the Bills' first game under new owners Terry and Kim Pegula, who completed their purchase of the franchise this week.

Brady is now 23-2 against AFC East rival Buffalo with the Patriots (4-2).

Kyle Orton went 24 of 38 for 299 yards with two touchdowns, an interception and a lost fumble in his second start for Buffalo since replacing EJ Manuel.

The Bills (3-3) have lost three of four.

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