Jake Rudock threw for 210 yards and two touchdowns and Iowa rolled past Indiana 45-29 on Saturday for its third straight win.
Mark Weisman had a pair of short TD runs for the Hawkeyes (5-1, 2-0 Big Ten), who scored all but seven of their points in the first half.
Iowa scored 28 points in the first quarter — surpassing its total in each of its first four games against Power 5 schools — and led by as much as 21.
Indiana pulled within 28-21, but Weisman closed the first half on a 1-yard TD run to give Iowa a 38-21 lead.
Tevin Coleman had 219 yards rushing for Indiana (3-3, 0-2), including TD runs of 83, 69 and 45 yards.
Hoosiers quarterback Nate Sudfeld left with an apparent injury in the first half and never returned.