Trevor Siemian ran for three touchdowns and passed for 258 yards to lead Northwestern past Penn State 29-6 on Saturday.
Siemian, who was 21 of 37, and the Wildcats (2-2, 1-0) established control early with short passes and ball-control offense that netted 361 yards.
Northwestern's defense held Penn State (4-1, 1-1) to 50 rushing yards and just 266 overall, pressuring Penn State quarterback Christian Hackenberg all game.
The WIldcats led 14-6 and broke the game open in the fourth when linebacker Anthony Walker intercepted Hackenberg and returned it 49 yards for a score.
On the next possession, Xavier Washington sacked Hackenberg, forcing a fumble. Jack Mitchell's ensuing 23-yard field goal made it a three-score margin. Siemian's one-yard plunge set the final score.
Northwestern's Matthew Harris was carted off late in the third after a collision with Hackenberg. Harris was responsive and offered the thumbs-up signal while leaving the field.