On a somber day for the Padres organization following the death of Hall of Famer Tony Gwynn at age 54, San Diego lost 5-1 to the Seattle Mariners on Monday night.
Kyle Seager hit a three-run homer in the first inning, Brad Miller added a solo shot, and Seattle's Chris Young threw six shutout innings against his former team.
Gwynn died earlier Monday of oral cancer, a disease he attributed to years of chewing tobacco.
San Diego was shut out by Young (6-4) and a pair of relievers until Carlos Quentin hit a solo homer leading off the ninth.
Seager's homer came on a 3-0 pitch from San Diego starter Tyson Ross (6-6).
Robinson Cano added an RBI double as Seattle scored all five runs in the first two innings.