Jedd Gyorko hit two home runs off Jose Fernandez, leading Tyson Ross and the San Diego Padres to a 10-1 victory over the Miami Marlins on Friday night.
Gyorko, who came into the game hitting just .146, connected for a two-run shot in the second and a grand slam in the sixth. The six RBIs set a career high.
The Padres, who came in averaging a major league-low 2.6 runs per game, snapped a three-game losing streak. It was their highest-scoring game since a 12-2 victory over Arizona on Sept. 25.
San Diego sent 11 men to the plate during a six-run sixth inning that broke it open. The Padres' previous high for runs in a single game this season was six.
Fernandez (4-2) was charged with six runs and six hits in five-plus innings. The right-hander, who won the NL Rookie of the Year award last season, was 2-0 with a sparkling 0.60 ERA in his previous four starts.
Ross (4-3) was working on a shutout before Marcell Ozuna homered in the seventh inning. The righty allowed four hits and struck out eight in seven innings.
Tim Stauffer and Kevin Quackenbush each pitched an inning to close out the combined four-hitter.
San Diego won for just the third time in 10 games and snapped the Marlins' five-game winning streak.
Gyorko's fourth homer in the second came after Yasmani Grandal reached on a throwing error by first baseman Garrett Jones.
Everth Cabrera sparked the Padres' biggest scoring inning of the season with a leadoff single in the sixth. Seth Smith singled and Grandal walked to load the bases for Gyorko, who turned on a 2-0 fastball and hit it into the second deck of the Western Metal Supply Building down the left-field line.
It was Gyorko's second career multihomer game and his second grand slam.
Fernandez had beaten the Padres in two previous starts by giving up just five hits in 14 2-3 scoreless innings with 18 strikeouts.
NOTES: Marlins RHP Carlos Marmol was struck in the back by a ball off Kyle Blanks' bat while stretching during San Diego's batting practice. Marmol said he was fine. ... Barring an injury, Padres 3B Chase Headley (strained right calf) will be activated from the 15-day DL on Saturday. Headley was scheduled to play Friday night with Single-A Lake Elsinore. ... The San Diego State men's basketball team that won the Mountain West Conference regular-season title and reached the Sweet 16 in the NCAA Tournament was honored before the game. ... Marlins RHP Nathan Eovaldi (2-1, 2.78 ERA) opposes Padres LHP Eric Stults (1-3, 5.40) on Saturday night.