Nick Hundley hit a three-run homer off White Sox ace Chris Sale in the first inning Wednesday and the San Diego Padres defeated Chicago 8-0.
Sale gave up six runs on six hits and a walk in 2 2-3 innings.
Xavier Nady drove in the first Padres' run with a two-out single in the first. San Diego added single runs in the second and third.
Andrew Cashner pitched three shutout innings for the Padres. He gave up two hits and no walks, and struck out three.
Cody Decker, a non-roster catcher, homered for San Diego in the eighth off White Sox lefty David Purcey.