Shane Southwell and Thomas Gipson scored 20 points apiece and Marcus Foster added 15 as Kansas State beat West Virginia 78-56 on Saturday.
Eron Harris had 21 points while Juwan Staten contributed 16 points and 11 rebounds to pace the Mountaineers (10-8, 2-3 Big 12).
Kansas State's lockdown defense continues to blossom as the Wildcats limited West Virginia to 32.7 percent shooting (16 of 49).
The Mountaineers entered averaging 79.9 points per game while shooting just under 46 percent. The 22-point loss was the largest loss of the season for the Mountaineers.
The game was West Virginia coach Bob Huggins' second trip back to Manhattan after spending one season at the helm of the Wildcats program during the 2006-2007 season.
Kansas State (14-4, 4-1) trailed for just 2:19 of the contest and led for the final 35 minutes.