Kayla McBride scored 15 points and Taya Reimer added 14 to lead a balanced offense in No. 5 Notre Dame's 76-54 win over Penn on Saturday.
This was believed to be the first time a top five women's team had played at the Palestra since Connecticut faced Saint Joseph's a decade ago. It also was the Irish's first game at the historic arena in 32 years.
The game marked the return of Notre Dame forward Natalie Achonwa, who missed the first three games while recovering from surgery to repair a torn meniscus in her right knee. The senior was supposed to miss at least a month, but returned in just three weeks.
She started for the Irish (4-0) and had four points in 14 minutes.
Katy Allen and Sydney Stipanovich each scored 11 to lead Penn (0-2).
The contest was Notre Dame's first road game of the season, although it served as a homecoming for Notre Dame coach Muffet McGraw, who starred a few miles away at Saint Joseph's in the late 1970s.