A healthy defense would have trouble against Peyton Manning.
So when six starters are sidelined, the task becomes much tougher.
The New England Patriots may find themselves in that predicament on Sunday night when Manning leads the Denver Broncos and their NFL-best offense into Gillette Stadium.
Starting safety Steve Gregory says the Patriots have a lot of defensive backs who are hurt, but it's the time of the season where that happens.
Gregory missed the Patriots' 24-20 loss to the Carolina Panthers on Monday night with a broken thumb and his status for the Denver game is unknown.
Starting cornerback Alfonzo Dennard also was sidelined with a knee injury and is expected to miss Sunday night's game. The other starting cornerback, Aqib Talib, couldn't finish the game because of a hip injury.
AP NFL website: www.pro32.ap.org