Jerian Grant and Garrick Sherman scored 15 points each and No. 21 Notre Dame won for the second game in three days, 80-49 over Stetson on Sunday.
Pat Connauhgton added 10 points for the Irish (2-0), while Sherman led the team with nine rebounds. Senior point guard Eric Atkins finished with eight points, leaving him five short of 1,000 for his career.
Reserve Brian Pegg led the Hatters (0-2) with 13 points and Willie Green added eight points and nine rebounds.
The Irish took a double-digit lead less than 5 minutes in as they improved to 48-0 at home in November under coach Mike Brey.