Updated

Indianapolis, IN (SportsNetwork.com) - Indianapolis Colts wide receiver Reggie Wayne suffered a knee injury that could be significant during Sunday's game against Denver.

Wayne was hurt while trying to catch a low pass from Andrew Luck in the fourth quarter of the 39-33 Colts win.

"Prayers and much love for #87 Reggie...let's pray his right knee gets miracle news!!!!!! Love that man and pray for good news!!!!!!" Colts owner Jim Irsay wrote on Twitter early Monday morning.

Wayne is the Colts' leading receiver with 38 catches for 503 yards and two touchdowns.