Antonio Andrews ran for 155 yards on 27 carries and had two touchdowns to lead Western Kentucky to a 31-10 victory over Louisiana-Monroe on Thursday night.
Western Kentucky (4-2, 1-1 Sun Belt) scored on its first two possessions, with Brandon Doughty throwing a 33-yard scoring pass to Willie McNeal and a 17-yarder to Leon Allen.
Doughty was 24 of 36 for 370 yards, an FBS school record for Western Kentucky.
Louisiana-Monroe (2-4, 1-2) scored 10 straight points after falling behind 14-10. Jyruss Edwards scored from a yard out and Justin Manton made a 34-yard field goal midway through the second quarter.
The Hilltoppers put it out of reach in the third quarter, outscoring the Warhawks 10-0 on Andrews' 6-yard touchdown run and Garrett Schwettman's 22-yard field goal. Allen added a late 5-yard touchdown run.
The nation's leading rusher with 882 yards, Andrews also leads the nation with nine rushing touchdowns.