Marion Grice scored four touchdowns, two on passes from Taylor Kelly, and Arizona State used consecutive big plays in the third quarter to race past Southern California 62-41 on Saturday night.
Arizona State (3-1, 1-1 Pac-12) trailed by 1 after USC opened the third quarter with a quick scoring drive.
The Sun Devils ran away from the Trojans after that, scoring a pair of touchdowns 47 seconds apart.
Kelly orchestrated the first, hitting D.J. Foster in stride for a 74-yard touchdown pass. Alden Darby was next, stepping in front of a pass by Cody Kessler for a 46-yard interception return that put the Sun Devils up 34-21.
Tre Madden and Justin Davis each scored three touchdowns for USC (3-2, 0-2 Pac-12).
It wasn't nearly enough with Arizona State piling up yards while scoring its most points ever against the Trojans and matching the most ever scored against USC.