The Colts will be missing three injured starters this weekend.
Coach Chuck Pagano says Friday that running back Ahmad Bradshaw, defensive lineman Ricky Jean Francois and Pro Bowl safety LaRon Landry will miss Sunday's game at Jacksonville.
Bradshaw missed practice all week with a neck injury, and his absence means newly acquired Trent Richardson will inherit a heavier workload.
Landry is still recovering from an ankle injury that kept him out of last week's game at San Francisco, and Jean Francois has not been back to work since leaving Sunday's game with a groin injury.
Indy (2-1) also listed safety Joe Lefeged as questionable with a knee injury, and receiver T.Y. Hilton as probable with a toe injury.
Linebacker Pat Angerer, safety Antoine Bethea and center Samson Satele are all probable.
AP NFL website: www.pro32.ap.org