Luis Rey converted a penalty kick two minutes from time to propel America to a 1-0 win over Monterrey on Saturday, lifting the club to the top of the Mexican Apertura table.
Coming off a comfortable 4-1 thrashing of UNAM last week, the hosts enjoyed a majority of the possession and fired 13 shot attempts, four of which were on target.
Despite the statistical advantage, America struggled to find the back of the net from the run of play and seized an opportunity in the 88th minute when Monterrey's Ricardo Osorio was whistled for a handball in the area, resulting in a penalty kick.
Rey lined it up from 12 yards out and fired it home to the bottom left corner to send America to the top of the table with 19 points, two clear of second- place Morelia.
Elsewhere in Mexico on Saturday, Joel Andrade ripped home an equalizer just past the hour mark as Atlante battled Morelia to a 2-2 draw, while Pachuca and UNAM played to a scoreless stalemate.
Guadalajara built a three-goal advantage only to see it erased via three strikes in the final 14 minutes to settle for a 3-3 draw with Tigres, while Carlos Ochoa's 43rd minute penalty was enough to lift Jaguares to a 1-0 result over Leon.
Rafael Figueroa scored four minutes from time to rescue a point for Santos in a 2-2 draw with Atlas and Saturday's slate wrapped up with Tijuana cruising to a 3-0 victory over Veracruz.
Friday's action saw Diego de la Torre score the only goal of the match in a 1-0 win for Queretaro over Puebla, while Cruz Azul netted a pair of second-half goals to beat Toluca by a 2-1 score.