Updated

Top-seeded American favorite Sam Querrey succumbed to a compatriot Tuesday at the Hall of Fame Tennis Championships.

Tim Smyczek took out the 2009 Newport runner-up Querrey in 6-4, 7-6 (10-8) fashion on the grass courts at the International Tennis Hall of Fame and Museum.

Meanwhile, third-seeded Dutchman Igor Sijsling avoided an opening-round upset by beating Italian Matteo Viola 6-4, 6-1, but more upsets came when 6-foot-10 Croat Ivo Karlovic decked fifth-seeded Frenchman Edouard Roger-Vasselin 7-6 (7-5), 6-4, and American Jack Sock topped sixth-seeded Aussie Marinko Matosevic, 6-2, retired.

Also on Day 2, Indian wild card Prakash Amritraj whipped Italian Flavio Cipolla 6-2, 6-3 and Canadian Vasek Pospisil overcame American Denis Kudla 1-6, 6-3, 6-3. Amritraj was a Newport runner-up back in 2008.

This week's second seed, John Isner, defeated former Wimbledon champion Lleyton Hewitt in last year's Newport finale for his second straight title here.

The winner of this $520,000 event will claim $78,000.