Arm fatigue led to Arizona starter Wade Miley seeing limited in action in Spring Training.
New Milwaukee starter Kyle Lohse barely had a training camp at all.
The two hurlers make their season debuts on Friday night when the Brewers host the Diamondbacks in the opener of a three-game series.
Despite coming off the best season of his 12-year career, Lohse did not come off the free agency market until signing a three-year deal with the Brewers on March 25. Part of the reason he lasted so long was because he turned down a $13.3 million qualifying offer from the St. Louis Cardinals in November, so the signing also cost the Brewers a first-round draft pick.
Still, Milwaukee got a 34-year-old right-hander who went 16-3 with a 2.86 earned run average in 33 starts a season ago. Lohse is ready to make Friday's start despite logging just one appearance that spanned 3 2/3 innings in the spring as he spent his offseason working out on his own.
Lohse has faced the Diamondbacks 11 times in his career, going 3-2 with a 4.48 ERA.
Miley, meanwhile, avoided a disabled list trip despite throwing just 13 1/3 innings over four Spring Training starts due to arm fatigue in his left shoulder. The Diamondbacks hope that the southpaw can duplicate his phenomenal campaign from last season, when he set Arizona rookie records with 16 wins, 29 starts and 194 2/3 innings.
The 26-year-old was 16-11 with a 3.33 ERA in 32 total appearances and was named to the All-Star team before finishing second in the NL Rookie of the Year voting.
Miley's numbers would have been even better had he not faced the Brewers last season. He allowed 11 earned runs and 16 hits over 9 2/3 combined innings in two meetings, yielding eight runs, three homers and eight hits over 3 2/3 frames in his lone outing at Milwaukee on June 30.
Arizona is coming off a series victory over the St. Louis Cardinals to begin the season, winning Wednesday's rubber match 10-9 in 16 innings.
Martin Prado extended the game with a sacrifice fly in the 12th inning that scored Cliff Pennington, who then drove in the winning run with a single in the bottom of the 16th.
Prado, Gerardo Parra and Paul Goldschmidt all homered and finished with three hits, while reliever Josh Collmenter got the win after allowing one run over five innings of relief. He was able to finish out the game despite having thrown 1 2/3 scoreless innings out of the bullpen a day earlier.
"They just hung in there. It's just a great contribution. They didn't panic when we got behind," Arizona manager Kirk Gibson said of his club. "Just outstanding. A great win."
Milwaukee opened the season with an extra-inning victory over the Colorado Rockies on Monday, but dropped the final two games of the set and suffered the series loss with Wednesday's 7-3 setback.
Rickie Weeks connected on a solo homer among his three hits and Ryan Braun went 2-for-2 with a pair of walks, an RBI and a run scored. Starter Wily Peralta gave up four runs on six hits and three walks over 5 1/3 frames to take the loss.
"I feel behind a couple of guys, but I'll be alright," Peralta said. "I just had a hard time getting ahead of hitters. That's just part of the game."
While Milwaukee's starters didn't give it much during the series, closer John Axford also raised some alarms. He served up a solo homer in Monday's win to suffer a blown save, then yielded another two home runs and three runs total while recording just two outs in Wednesday's loss.
The Brewers and Diamondbacks split six meetings last season, with each team taking two of three at home.