Updated

Russ Smith had another big night, leading four players in double figures with 27 points, and top-seeded Louisville is into the Midwest Region semifinals.

The Cardinals put on a defensive clinic as they dismantled Colorado State 82-56 on Saturday. Louisville forced the eighth-seeded Rams into a season-high 20 turnovers, made Colton Iverson look as invisible as a 6-foot-10 guy can be and limited one of the nation's best rebounding teams to 24 boards, more than a dozen below their average.

It was the 12th straight win for Louisville (31-5), which will play the winner of Saint Louis-Oregon on Friday in Indianapolis.