Troy Daniels had 23 points, Juvonte Reddic scored 21 and VCU routed Akron 88-42 on Thursday night in the most lopsided victory by a fifth-seeded team over a No. 12 in NCAA tournament history.
The previous mark was set by Wyoming in a 35-point win over Howard in 1981 and matched by Tennessee against Long Beach State in 2007, according to STATS.
The Rams (27-8) will play fourth-seeded Michigan on Saturday for a spot in the round of 16.
Akron (26-7) was seriously short-handed, and it showed.
In addition to playing without suspended point guard Alex Abreu, the Zips had other problems as well. Starting guard Brian Walsh and reserve center Pat Forsythe were limited by the flu, and reserve guard Deji Ibitayo wasn't even in uniform because of back spasms.