Hot-shooting Travis Wallace scored 25 points and North Florida shot 59.6 percent from the field in an 85-78 victory over Lipscomb in the regular-season finale for both teams.
The Ospreys were 31 of 52 from the field, with Wallace making 8 of 11 and 9 of 13 from the line.
Ray Rodriguez scored 16 points, Andy Diaz had 11 and Parker Smith 10 for North Florida (13-18, 8-10 Atlantic Sun Conference).
Deonte Alexander had 19 points, Carter Sanderson scored 16, Stephen Hurt 13 and Khion Sankey 12 for the Bison (12-17, 7-11), who had won two straight coming in.
The Ospreys trailed 51-36 with 16:53 left, and Lipscomb led 59-45 with 11:35 remaining, but North Florida went ahead 73-72 on Rodriguez's 3-pointer at 3:30.
Lipscomb's Sanderson tied it a 78 with two free throws, but Wallace's layup with 1:11 left put the Ospreys ahead for good.