Notre Dame coach Brian Kelly says defensive end Kapron Lewis-Moore has a "significant" leg injury.
Lewis-Moore injured his right leg and had to be helped off the field in the first half of Monday night's 42-14 loss to Alabama in the BCS championship game.
Kelly didn't provide specifics for the senior's condition.
Lewis-Moore missed the last six games of the 2011 season with a knee injury. He started 12 games this season and had six sacks.