Kayla McBride scored 21 points and Skylar Diggins added 19 to help No. 5 Notre Dame upset top-ranked Connecticut 73-72 on Saturday in the Big East conference opener for both teams.
Trailing 73-72 with 6 seconds left, Kaleena Mosqueda-Lewis missed a 3-pointer from the corner and the Irish (12-1, 1-0 Big East) got the ensuing rebound and ran out the clock as Diggins threw the ball into the air at the final buzzer.
The Irish have had the Huskies' number the past few years, winning five of the past six meetings, including two in the Final Four the past two seasons.
Mosqueda-Lewis and Stefanie Dolson each scored 17 points to lead UConn (12-1, 0-1).
The rivalry, which UConn leads 29-9, has grown into one of the biggest in women's college basketball.