Texans coach Gary Kubiak says cornerback Johnathan Joseph, linebacker Bradie James and offensive linemen Derek Newton and Antoine Caldwell will miss Sunday's game at Tennessee.
All of those players sat out Friday's workout, as did cornerback Alan Ball, who has a sore foot. Kubiak had already ruled out linebacker Brooks Reed, who's sidelined indefinitely with a groin injury.
The Texans (10-1) can clinch a playoff spot with win in Tennessee (4-7).
Joseph (hamstring), Caldwell (hamstring), Newton (right knee) and James (hamstring) have sat out practices all week. Ball will be a game-time decision.